mimic miRNA, and antimiR. According to publications, high siRNA concentrations during transfection may result in non-specific off-target effects. Using as little siRNA as possible can improve the ...

He has led licensing deals across a range of novel modalities including antisense oligos (ASO), miRNA/siRNA and antibody technologies, and he has built and managed diverse portfolios of cutting ...

is a biological process in which RNA molecules—microRNA (miRNA) and small interfering RNA (siRNA)—inhibit gene expression, typically by binding to messenger RNA (mRNA) and triggering its ...

siRNA pathways may generate 5′ overhang–containing dsRNA molecules. For example, slicing of an mRNA or a ssRNA guided by an Argonaute loaded with a microRNA (miRNA) or siRNA will produce 5 ...

RNA-based technologies are a powerful molecular biology toolbox, empowering scientists to decipher the complexities of living ...

We also show that miR-4488 is downregulated when the viral levels are lowered using siRNA, suggesting that this microRNA is involved in the host-response to infection. Since miR-4488 levels closely ...

3. miR-770 derived from THP1 cells enhances apoptosis and counteracts drug resistance. VEGF-derived siRNA and let-7 miRNA target AS1411, which inhibits nucleolin proteins, thereby increasing drug ...

Its lead candidate, TTX-MC138, targets microRNA-10b—a master regulator of metastasis ... Beyond TTX-MC138, its preclinical pipeline includes: TTX-siPDL1, an siRNA modulator of PD-L1 for solid tumors ...

Dental caries (tooth decay) is a common oral health condition that often causes significant pain and discomfort and may even ...