RNAi (RNA interference) is a biological process in which RNA molecules—microRNA (miRNA) and small interfering RNA (siRNA)—inhibit gene expression, typically by binding to messenger RNA (mRNA ...

SLXN), a clinical-stage biotech advancing RNA interference (RNAi) therapies for KRAS-driven cancers, has reported compelling new preclinical data for SIL-204, its next-generation siRNA candidate.

Our group retains an interest in the areas of structure-function studies of RNA interference mediated by siRNA pathway, and on post-translation histone and DNA modifications impacting on epigenetic ...

checklist identifies minimal reporting parameters for aspects of high-throughput RNA interference (for example, siRNA and small hairpin RNA) screens, usually in conjunction with cellular assays ...

Researchers from Eli Lilly & Co. reported preclinical data on LY-3954068, a MAPT small-interference RNA (siRNA) strategy in AD models. The therapy is designed to reduce tau protein synthesis by ...

Although siRNA interference of EGFR or HER3 effectively suppressed the HER2 internalization in cells stably expressing WT forms of HER2, such internalization was not affected in the cell lines ...

In brief, cells were cultured in a six-well plate at 70%-90% confluency. For RNA interference, 2500 ng siRNA and 3.75 μl Lipofectamine 3000 reagents were mixed and then added in each well. For ...

Also in March 2025, Wave announced that the company met with the U.S. Food and Drug Administration (FDA) on WVE-N531 to ...

In obesity, we are evaluating WVE-007, our INHBE GalNAc-siRNA in our ongoing INLIGHT clinical trial, and are on track to deliver the first clinical data in the second half of this year.

As exciting as local contests might prove, the backdrop for any elections – in Singapore and elsewhere – includes a graver potential threat: Foreign interference. Hopefully, this rising threat ...

"We speak with one voice against the unprecedented government overreach and political interference now endangering American higher education," Tuesday's letter read. "We are open to constructive ...