Toll-like receptors (TLRs) use multiple downstream signaling pathways. New data suggest that components of the tumor necrosis factor receptor signaling pathway are involved in signal transduction ...

Mammalian Toll-like receptors (TLRs) recognize conserved products of microbial metabolism and activate NF-κB and other signaling pathways through the adapter protein MyD88. Although some cellular ...

Working on mice deficient in MyD88 (an essential protein in the classical Toll signaling pathway) they showed that TIRAP is part of an alternative signaling route for immune responses induced by ...

A University of Minnesota Medical School-led research team has discovered that a cancer signaling pathway has previously ...

To drill down into the details, the researchers looked specifically at the Toll signaling pathway and immune deficiency pathway, which is also known as the imd pathway.

The gene expression data pointed researchers to two immune-system pathways as potentially being involved in the parasite-triggered activation: the Toll and IMD signaling pathways.

The Wnt pathway plays a wide variety of roles in animal and human development, and the ability to regulate it with light will allow researchers to better study its assorted functions.

Instead, he and his colleagues found that the proteinases carve up a protein known as fibrinogen, leaving behind fragments that signal through the crucial toll-like receptor 4 to activate the ...

Toll-like receptors do not involve the ITAM motif in their signal pathways. However, the team has demonstrated that toll-like receptor-dependent signaling pathways do converge on CARD9, but then are ...

Among other genes, Earth flies activated something called the Toll signaling pathway, which scientists have long known flies use to fight off fungi.

Crosstalk among T-cell CX3CR1, immune checkpoints and toll-like receptor 4 signaling pathway in BCG-unresponsive nonmuscle invasive bladder cancer: Mechanism of action of OncoTherad Nano-Immunotherapy ...