Treatment with the fully brain-penetrating NLRP3 inflammasome inhibitor also sharply limited weight regain following the cessation of semaglutide therapy and reduced multiple cardiovascular, ...

NLRP3 is a member of a family of proteins known as inflammasome receptors and is a key component of the NLRP3 inflammasome, which is implicated in a host of diseases characterised by runaway ...

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. Ablation of RIPK1 in αβT cells results in ...

This month's cover highlights the article Sertm2 is a Conserved Micropeptide that Promotes GDNF-mediated Motor Neuron Subtype Specification by Jun-An Chen, Fang-Yu Hsu and colleagues. The micropeptide ...

International PhD Program in Biomedical Engineering, College of Biomedical Engineering, Taipei Medical University, Shuang-Ho Campus, New Taipei City 110, Taiwan International PhD Program in Biomedical ...

The California-based biopharma is developing cavrotolimod, a spherical TLR9 agonist that is designed to trigger innate and adaptive immune responses by binding to and activating the protein TLR9. In ...

4 Guy's and St Thomas’ NHS Foundation Trust, London, UK Background Muscle wasting and weakness (sarcopenia) are commonly associated with COPD causing frailty and reduced quality of life. The ...

Rheumatoid Arthritis (RA) is a clinically significant, refractory autoimmune disease, characterized by uncontrolled inflammation and cartilage destruction in the affected joints, eventually leading to ...