Sickle-cell trait haplotype distribution shows the ... Although caused by a single amino acid substitution, SCA is a clinically heterogeneous disease for which multiple factors influence a ...

Why is knowing the atomic structure of molecules useful? Learn why, and how information like this about protein structure is shared through a publicly available database.

Hydroxyurea remains effective long-term in reducing emergency department visits and hospital days for children living with ...

Children with sickle cell disease, a chronic hemolytic anemia, present with a wide variety ... is the substitution of valine for glutamic acid at the sixth position of the β globin chain (Glu6Val).