A SIRT3 protein deficiency in skeletal muscles, which are attached to bones, was related to pulmonary hypertension associated with heart failure with preserved ejection fraction (PH-HFpEF), a study ...

The use of 3-methyladenine (3-MA) to inhibit autophagy blocked NLRP3 inflammasome activation and inhibited the M1 polarization of macrophages. miR-421 targeting inhibited SIRT3 protein expression in ...

Background: High doses of doxorubicin put cancer patients at risk for developing dilated cardiomyopathy. Previously, we showed that doxorubicin treatment decreases SIRT3 (sirtuin 3), the main ...

Acetylated protein and activity of its enzymes were detected. Key Results: Sirt3 was significantly down-regulated in AF patients and rabbit/HL-1cell model, resulting in the abnormal expression of its ...

SIRT3 is a deacetylase that regulates mitochondrial protein acetylation and thus plays a role in metabolism, redox balance, and mitochondrial dynamics. This way, it protects mitochondria from damage.

In addition, perampanel increased Sirt3 protein expression, enhanced the activities of mitochondrial enzyme IDH2 and SOD2, and preserved BBB function in vitro. Knockdown of Sirt3 using specific siRNA ...

Amyloid beta has been shown to damage mitochondria - the metabolic engine for cells - by interfering with SIRT3, a protein that preserves mitochondrial functions and protects neurons.

SIRT3–AMP-Activated Protein Kinase Activation by Nitrite and Metformin Improves Hyperglycemia and Normalizes Pulmonary Hypertension Associated With Heart Failure With Preserved Ejection Fraction ...

A natural compound from magnolia bark can protect the heart from hypertrophy by activating SIRT3, a protein associated with delayed aging, stress resistance and metabolic regulation. Injected ...