A natural compound from magnolia bark can protect the heart from hypertrophy by activating SIRT3, a protein associated with delayed aging, stress resistance and metabolic regulation. Injected ...

Mitochondrial sirtuin 3 (SIRT3) mediates cellular resistance toward various forms of stress. Here, we show that in mammalian cells subjected to hypoxia and staurosporine treatment SIRT3 prevents ...

image: Decreased levels of SIRT3 triggers loss of interneurons in Alzheimer's disease mouse models. view more Credit: Cheng et al., JNeurosci 2019. A ketone-supplemented diet may protect neurons ...

Sirtuin proteins promote longevity in many organisms. Increased expression of one sirtuin protein, SIRT3, has been linked to increased human lifespan. New data, indicate that Sirt3 helps protect ...

Age-related decline in two sirtuin enzymes alters mitochondrial dynamics, weakens cardiac contractions Date: August 24, 2021 Source: University of South Florida (USF Health) ...

In the absence of SIRT3, mitochondrial proteins become hyperacetylated, which can impair function. Human studies show that sedentary patients over 60 years old have nearly 40 percent less SIRT3. Mice ...