She was in her third year of pursuing a doctorate in biochemistry, according to her "About" section, and was working on "characterizing the O-GlcNAcylation modification on NOD2." ...

This is what causes the inflammation. CARD15 (also called NOD2) is another gene linked to IBD. This gene carries the instructions for making a protein that helps your immune system work right.

EXL01, a Faecalibacterium prausnitzii (F. prau)-based therapeutic, “leverages the unique peptidoglycan structure of the F. prau to activate the NOD2 pathway in macrophages and monocytes.

Genomic sequencing for immune thrombocytopenia (ITP) may help prevent misdiagnosis and shape treatment decisions, according to results of a recent study published in Blood Advances. “In this pilot ...

Although the idea that CD may result from abnormal host–microbe interactions is appealing, there is no direct experimental evidence that links loss of Nod2 function in small intestinal crypts with ...

Since RIPK2 is essential for NOD2 signaling and YOD1 stabilizes RIPK2, overexpression of YOD1 strongly increased L18-MDP-induced NF-κB and MAPK activation as well as cytokine production (Appendix Fig.

Background: Systemic activation of multiple immune receptors, such as Toll-like Receptor (TLR), Nucleotide oligomerization domain (NOD) like, and Stimulator of interferon genes (STING) may be required ...

Dysbiosis is when there is an issue with the diversity of someone’s gut bacteria. Understand more about the causes and treatments for this condition.

The association between NOD2 loss-of-function and heightened immune response to anti-PD1 was experimentally tested in Nod2 -null C57BL/6J (Nod2fs) mice. Nod2fs mice transplanted with a syngeneic cell ...

John F. Valentine, MD, is a Professor of Medicine at the University of Utah School of Medicine in the Division of Gastroenterology, Hepatology and Nutrition and specializes in ulcerative colitis and ...