It follows a previous report showing that the Werner syndrome protein WRN and its interacting protein WRNIP1 are indispensable for translesion DNA synthesis (TLS) by Y-family DNA polymerases (Pols).

The study proposes that ADA2's regulation of TLR9 activation in pDCs could explain the functional differences among the three classes of CpG ODNs and suggests that synergistic activation of TLR9 ...

Consequently, Toll-like receptor 9 (Tlr9) in DCs was activated, thereby leading to robust production of IL-12 p40 and IL-6. These activities of CXCL14 were not observed in Tlr9-deficient DCs. Moreover ...

Background: Toll-like receptors (TLRs) are involved in the pathophysiology of cerebral ischemia/reperfusion injury. TLR9 is an intracellular TLR which is located in the endosome and recognizes CpG-DNA ...

ABOVE: Researchers employ DNA origami (gray) to design cancer vaccines carrying tumor antigens (green) and CpG adjuvants (yellow) at DNA ends. Wyss Institute at Harvard University . T he immune system ...

The nanoscale distances between the CpG-binding domains in effective TLR9 assemblies revealed by structural analysis fell right into the range of what we hypothesized we could mirror with DNA ...

The nanoscale distances between the CpG-binding domains in effective TLR9 assemblies revealed by structural analysis fell right into the range of what we hypothesized we could mirror with DNA ...

Aims: To study possible interactions between CpG DNA (TLR9 ligand) and MDP using primary human cells of differing NOD2 genotypes. Subjects: NOD2 wild-type healthy controls (n = 7) and NOD2 homozygous ...

WALTHAM, Mass., Nov. 3, 2023 /PRNewswire/ -- Immunitas Therapeutics ("Immunitas"), a clinical stage precision immunotherapy company committed to discovering and developing novel, differentiated ...

CpG 1018 is a proprietary immune adjuvant made up of short, unmethylated cytosine-phosphate-guanine oligodeoxynucleotides (CpG ODNs). Its components mimic bacterial DNA to activate innate immunity ...

Tallac Therapeutic’s TRAAC platform is designed to deliver a potent and differentiated TLR9 agonist (T-CpG) for targeted immune activation via systemic administration. TAC-001 is comprised of T-CpG ...

Toll-like receptor 9 (TLR9), which is expressed by the body’s immune cells, “senses” foreign unmethylated CpG-rich DNA (CpG DNA) to trigger innate immune responses that are the first line of ...