To make matters worse, existing standards for alignment are based on k-mer matching, which can require processing enormous numbers of seeds when aligning repetitive sequences. The manifold nature of ...

Engineered variants of CRISPR enzymes with diverse NLS sequences have shown success in promoting nuclear localization and efficient DNA editing. The study applied a new approach that installed ...

Among the most promising are recombinases: enzymes that can precisely rearrange or insert DNA sequences without introducing double-stranded breaks. Unlike CRISPR, which acts like molecular scissors, ...

He then saw that a repetitive sequence “sort of pops up.” “I was used to searching for patterns in things as part of my [military] training,” he said. “I started to see a pattern of tRNA ...

Purpose Facioscapulohumeral muscular dystrophy (FSHD) is a genetic disorder caused by contraction or hypomethylation of the D4Z4 repeat array located at chromosome ... based on fluorescence labelling ...

Abstract: Existing zero-sequence current (ZSC) elimination methods have unsatisfactory ... This article proposes a new ZSC elimination strategy based on frequency-adaptive repetitive control (FARC) ...

More information: Pre-symptomatic Parkinson's disease blood test quantifying repetitive sequence motifs in transfer RNA fragments, Nature Aging (2025). DOI: 10.1038/s43587-025-00851-z Journal ...