An elegant screening strategy unveils a molecular actor that connects widespread changes in mRNA processing with a nutrient-sensing protein modification.

A tiny chemical modification commonly found on messenger RNAs plays a surprisingly large role in how cells respond to stress, according to a study led by Weill Cornell Medicine investigators.

This manuscript characterizes a mutated clone of RNA polymerase I in yeast, referred to as SuperPol, to understand the mechanisms of RNA polymerase I elongation and termination. The authors present ...

The RNA m5C methylation modification, which adds a donor active methyl group ... is primarily responsible for catalyzing the formation of m5C at position C72 in tRNA Cys and tRNA Thr (Haag et al., ...

The tRNA carries the amino acids ... 16 The emerging epitranscriptomic field features a multitude of post-transcriptional modifications with the potential to affect gene expression by impacting ...

Conclusion: Our study demonstrates that HJURP is critical for promoting GC proliferation and chemoresistance through the regulation of the MYC/TOP2A transcriptional network ... Cells were harvested 48 ...

McKetta Department of Chemical Engineering, University of Texas at Austin, 200 E. Dean Keeton St. Stop C0400, Austin, Texas 78712, United States ...