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Activation of NF-κB is triggered by all TLRs from the plasma membrane and endosome, whereas TLR-induced IRF3 (TLR3 and TLR4) and IRF7 (TLR7–9) activation is initiated only from the endosome.

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Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. Host cells activate cell death pathways in ...

For instance, TLR4 recognizes lipopolysaccharide (LPS) from Gram-negative bacteria, triggering an inflammatory response and inducing the production of cytokines such as TNF-α, IL-1β, and IL-6 (164). 5 ...

The manuscript contains important findings regarding inflammatory macrophage subsets that have theoretical and/or practical applications beyond the field of rheumatology. The authors demonstrate with ...

Macrophages play a central role in initiating, maintaining, and terminating inflammation. For that, macrophages respond to various external stimuli in changing environments through signaling pathways ...

More than half of patients with ischemic stroke experience futile reperfusion, increasing the risk of death and disabilities despite a successful recanalization. The reason behind this is debated, and ...