This important study looks into the effect of exogenous CoA on the response of TLR4-activated macrophages. Specifically, CoA enhances the LPS response by examining metabolomics, 13C tracing, and ...

TLR4 activation by lipopolysaccharide, an outer membrane component of Gram-negative bacteria, can enhance seizures in rodents 4, 5, although this is a not a common cause of epilepsy.

Li et al found that, after TLR4 recognition of extracellular HMGB1, AP-1 and IRF3/5/7 are upregulated, promoting the transfer of NF-κB to regulate the expression of genes encoding inflammatory ...

Objective Recent evidence suggesting an important role of gut-derived inflammation in brain disorders has opened up new directions to explore the possible role of the gut-brain axis in ...

TLR4 is a membrane receptor that combines with LPS signaling molecules and relies on TRIF recruitment of RIPK1 and RIPK3 (Muendlein et al., 2022; Chen et al., 2022). Type I/II interferon can activate ...

AVIOT is launching its 2025 Spring/Summer Promo Tour with appearances at anime conventions across the United States. At each event, AVIOT will showcase and sell character voice earbuds and ...

Glycolipids with TLR4 agonistic properties can serve either as therapeutic agents or as vaccine adjuvants by stimulating the development of proinflammatory responses. Translating them to the clinical ...

The Correlated Quantum Materials (CQM) group focuses on theoretically studying emerging quantum phenomena in quantum materials. The core of our research focuses on the theoretical design and ...