First, the released mtDNA can bind to TLR9 on the surface of erythrocytes to induce an immune ... In addition, the released mtDNA activates PRRs such as NLRP3 and AIM2, recruiting ASC and procaspase-1 ...

Figure 2. cfDNA and the immunosuppressive microenvironment. TLR9, toll-like receptor 9; MyD88, myeloiddifferentiationfactor88; DAMP, damage-associated molecular patterns; NLRP3, NOD-like receptor ...

MNPs synergize with chemical additives, worsening cardiovascular injury through mechanisms like pyroptosis and NLRP3 inflammasome activation. Chemical pollutants could synergize with other health ...

Landmark exclusive option and license deal with Takeda for ACI-24.060 with $100 million upfront and additional potential milestones of up to about $2.1 billion plus royalties on sales upon ...

Landmark exclusive option and license deal with Takeda for ACI-24.060 with $100 million upfront and additional potential milestones of up to about $2.1 billion plus royalties on sales upon ...

A new year means a new Fierce Biotech Fundraising Tracker to record the significant amounts of venture capital being funneled into the industry. We're maintaining the criteria we used for last ...

Radiation therapy and immunotherapy in partnership may have the capability of delivering a therapeutic effect exceeding the sum of its parts. The possible relationship has been demonstrated in ...

Certain supplements, including cinnamon and aloe vera, may help lower blood sugar. However, further research is still needed to understand the exact effects. Some supplements may have a beneficial ...

Cannabis is a plant that has been in use for more than 4,000 years. There are a few different kinds of cannabis, including Cannabis sativa. Although research on cannabidiol (CBD) is still in its ...

Expert Rev Clin Immunol. 2013;9(8):735-747. A diet likely to be generally beneficial to IBD patients was developed from [37]. A recipe book was put together, and relevant companies approached for ...