These results suggest that SIRT3/SOD2 is required for regulating mitochondrial stress and plays a vital role in osteoblast differentiation and bone formation.

Mice with low levels of SIRT3 experienced a much higher mortality rate, more violent seizures, and increased interneuron death compared to the mice from the standard Alzheimer's disease model and ...

A natural compound from magnolia bark can protect the heart from hypertrophy by activating SIRT3, a protein associated with delayed aging, stress resistance and metabolic regulation. Injected ...

Sirtuin proteins promote longevity in many organisms. Increased expression of one sirtuin protein, SIRT3, has been linked to increased human lifespan. New data, indicate that Sirt3 helps protect ...

Furthermore, age-related SIRT1 and SIRT3 deficiency can impair cardiac function by altering mitochondrial dynamics, which play an important role in metabolic health and inflammatory response, the ...

However, SIRT3 levels also drop with age, so over time, the system is overwhelmed.” So it appears that age-related degeneration speeds up in the absence of SIRT3 in the system – at least among ...

They found the compound activates SIRT3, a protective protein associated with delayed aging, stress resistance and metabolic regulation. “Honokiol, by increasing SIRT3 levels, effectively blocked both ...