Mol Cancer Ther (2025) 24 (4): 497–510. Murine double minute 2 (MDM2) is an E3 ligase that inhibits the tumor suppressor protein p53. Clinical trials employing small-molecule MDM2/p53 interaction ...

5Department of Microbiology, Immunology and Tropical Medicine, The George Washington University Cancer Center, The George Washington University School of Medicine and Health Sciences, Washington, ...

Silent information regulator of transcription 1 (SIRT1) is a deacetylase that plays a pivotal role in the regulation of various biological processes. In this review, we explore the role of SIRT1 in ...

Tissue fibrosis represents an aberrant repair process, occurring because of prolonged injury, sustained inflammatory response, or metabolic disorders. It is characterized by an excessive accumulation ...

Hangzhou Medical College, Xihu District, Hangzhou, Zhejiang, 310013, P. R. China Key Laboratory of Neuropsychiatric Drug Research of Zhejiang Province, Hangzhou ...

The research goal of our team is to unravel molecular and cellular processesunderpinning vascular and cardiac dysfunction in the setting of elevated cardiometabolic risk. The impact of this research ...

When these genetically damaged cells are not fixed or eliminated, they can go on to multiply uncontrollability. A protein known as p53 can help to repress emerging tumors by stopping mutated cells in ...