Autophagy facilitates host defense against invading bacteria. Philpott and colleagues show that Nod1 and Nod2 link pathogen sensing to autophagy by recruiting the autophagy protein AGT16L1 to the ...

Some have noted Nod2 expression in paneth cells, which are located at the base of intestinal crypts and produce small antibacterial molecules called a-defensins. 8 This indicates that in the absence ...

Immune cells rely on NOD2 receptors to detect these muropeptides and keep bacterial populations in check. NOD2 abnormalities have been linked to inflammatory bowel disorders such as Crohn’s Disease.

NOD2 is a cytosolic pattern recognition receptor similar in structure and function to Toll like receptors (TLRs). It can recognize and respond to a component found in the cell wall of bacteria ...

The NOD2 receptors of herpes-infected cells showed no such activation. Next, the investigators compared human cells with intact NOD2 receptors and those with defective or missing NOD2 receptors.

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Mice that were genetically engineered to be deficient in Nod2 gained more weight than controls, a difference that became significant at 6 months and continued thereafter. In addition, temperature ...

Several recent Imhotex Ltd. patents describe novel analogues of muramyl dipeptide (MDP), desmuramylpeptides (DMPs), acting as nucleotide-binding oligomerization domain-containing protein 2 (NOD2) ...

“Once the NOD2 pathway trigger is initiated, the cells need a second, amplifying step to complete a full-strength immune response,” explained one of the study’s lead researchers, Che Stafford.