Their work focuses on targeting the NOD2 pathway, with the goal of reprogramming the immune system using precision microbiome effectors. Since March 2024, ALA has worked with Exeliom to support their ...

As a professor of pathology at the University of Michigan, Gabriel Nuñez’s life is dedicated to research on microbes and ...

Several studies have suggested that COVID-19 may increase a person’s risk of developing cancer or promote metastasis of existing cancer.

Mechanistic studies are underway to refine the company’s understanding of how NOD2 activation drives metabolic reprogramming in immune cells. Meanwhile, EXL01 is undergoing Phase II trials in ...

Results The expression of miR-10a was markedly decreased, while NOD2 and interleukin (IL)-12/IL-23p40 were significantly increased, in the inflamed mucosa of IBD patients compared with those in ...

NOD2, in turn, recognize not only peptidoglycan but also intracellular infections and epithelial invasion by pathogens. Recent studies have revealed a close relationship between gut microbiota ...

Targets to Therapies Initiative will de-risk drug development to expand foundational knowledge of underexplored drug targets through a multi-year research program Research community-driven survey ...

Patients with Crohn's disease who underwent primary ileocaecal resection and had preoperative corticosteroid use of ≥ 1000 mg had reduced corticosteroid use in the 5 years following surgery ...

Expert Rev Clin Immunol. 2013;9(8):735-747. A diet likely to be generally beneficial to IBD patients was developed from [37]. A recipe book was put together, and relevant companies approached for ...