The study proposes that ADA2's regulation of TLR9 activation in pDCs could explain the functional differences among the three classes of CpG ODNs and suggests that synergistic activation of TLR9 ...

CXCL14 bound CpG ODN with high affinity at pH 7.5, but not at pH 6.0, thereby enabling efficient delivery of CpG ODN to TLR9 in the endosome/lysosome. Furthermore, the CXCL14-CpG ODN complex ...

Background: Toll-like receptors (TLRs) are involved in the pathophysiology of cerebral ischemia/reperfusion injury. TLR9 is an intracellular TLR which is located in the endosome and recognizes CpG-DNA ...

To optimize their vaccine, which they named DoriVac, the team tested a variety of DNA origami blocks with different CpG spatial distributions. Each of them triggered helper T cells to adopt ...

The nanoscale distances between the CpG-binding domains in effective TLR9 assemblies revealed by structural analysis fell right into the range of what we hypothesized we could mirror with DNA ...

The nanoscale distances between the CpG-binding domains in effective TLR9 assemblies revealed by structural analysis fell right into the range of what we hypothesized we could mirror with DNA ...

Aims: To study possible interactions between CpG DNA (TLR9 ligand) and MDP using primary human cells of differing NOD2 genotypes. Subjects: NOD2 wild-type healthy controls (n = 7) and NOD2 homozygous ...

In vitro proof-of-concept data shows effective delivery of CpG to endosomal TLR9 via anti CLEC2D antibody, resulting in sustained myeloid and B cell activation, enabling induction of stronger T cell ...

Background CpG 1018 is a proprietary immune adjuvant made up of short, unmethylated cytosine-phosphate-guanine oligodeoxynucleotides (CpG ODNs). Its components mimic bacterial DNA to activate innate ...

Toll-like receptor 9 (TLR9), which is expressed by the body’s immune cells, “senses” foreign unmethylated CpG-rich DNA (CpG DNA) to trigger innate immune responses that are the first line of ...

This paved the way for a later discovery of TLR9 which when combined with synthetic CpG-A oligonucleotides leads to TLR9 stimulation for therapeutic purposes, a core of Checkmate's sole therapeutic.

Microbial nucleic acids in the extracellular milieu are recognized in vertebrates by Toll-like receptors (TLRs), one of the most important families of innate immune receptors. TLR9 recognizes ...