Microbial DNA sequences containing unmethylated CpG dinucleotides activate Toll-like receptor 9 (TLR9). We have found that TLR9 is localized to the endoplasmic reticulum (ER) of dendritic cells ...

Finally, TLR9 was shown to be required for NF-κB and JNK activation by CpG DNA. Taken together, these results clearly show that TLR9 is absolutely essential for CpG DNA (and by inference ...

The CpG motif has an elongated structure and attaches at two locations, one on each part of the TLR9 dimer, forming a 2:2 complex.Bottom row: Binding mode of TLR9 and antagonist DNA sequence.

Toll-like receptor 9 (TLR9), which is expressed by the body’s immune cells, “senses” foreign unmethylated CpG-rich DNA (CpG DNA) to trigger innate immune responses that are the first line of ...

TLR9 is a membrane-bound protein that detects these traces by recognizing a DNA sequence called Cytosine-phosphate-Guanine dinucleotide (CpG), a motif that is specific to bacteria and viruses.

The study proposes that ADA2's regulation of TLR9 activation in pDCs could explain the functional differences among the three classes of CpG ODNs and suggests that synergistic activation of TLR9 ...

CpG 1018 is a proprietary immune adjuvant made up of short, unmethylated cytosine-phosphate-guanine oligodeoxynucleotides (CpG ODNs). Its components mimic bacterial DNA to activate innate immunity ...

The TLR9 receptors bind cell-free DNA rich in unmethylated CpG sites – a hallmark of pathogenic DNA. As RBCs begin to lose their structure when they bind multiple CpG-containing DNA this leads to an ...

Checkmate Pharmaceuticals currently has one therapeutic in their pipeline known as Vidutolimod ("CMP-001"), a CPG-A TLR9 agonist, ... immune-stimulatory CpG DNA in 1994.

A DNA region with a C followed by G, connected via a phosphate (p), is known as a CpG dinucleotide (figure 1). Genes are DNA regions carrying primary information about the RNA and proteins ...

TLR9 is a membrane-bound protein that detects these traces by recognizing a DNA sequence called Cytosine-phosphate-Guanine dinucleotide (CpG), a motif that is specific to bacteria and viruses.