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Light-activated catalyst enables chiral synthesis with higher yields and less waste
The new approach involves binding a copper chloride to a chiral phosphine ligand—one that ... The team demonstrated their catalyst using a variety of alkyl halides, and in all cases, they found it ...
C&EN18d
Some Items of Interest to Process R&D Chemists and Engineers
Vertex Pharmaceuticals, 86-88 Jubilee Avenue, Milton Park, Abingdon OX14 4RW, U.K.
Chemistry World20d
Light-activated catalyst sorts mirror-image molecules by resetting carbon–halogen bonds
The new catalyst features a copper chloride unit bound to a bulky, chiral phosphine ligand that modulates its reactivity. When activated by light, the excited catalyst engages in a single electron ...
Nature26d
Light wins uphill battle to solve enduring problem in organic synthesis
The protocol for the new reactions is strikingly simple: mix an alkyl halide with copper(i) chloride and a commercially available chiral ligand (an organic molecule that binds to the copper atoms ...
C&EN29d
From Bones to Bugs: Structure-Based Development of Raloxifene-Derived Pathoblockers That Inhibit Pyocyanin Production in Pseudomonas aeruginosa
Center of Pharmaceutical Engineering (PVZ), Technische Universität Braunschweig, Franz-Liszt-Straße 35a, 38106 Braunschweig, Germany Helmholtz-Institute for Pharmaceutical Research Saarland (HIPS) - ...