This promiscuous binding activity means that miRNA can act on many different mRNAs, potentially silencing hundreds of genes simultaneously. In contrast, when RNAi is guided by siRNA, the entire ...

The exosomal Argonaute 2 (AGO2) protein forms a complex with siRNAs, which is essential for siRNA-mediated gene silencing in bacteria. Even though the delivered siRNA was designed to possess full ...

PH-762, an INTASYL siRNA compound targeting PD-1, is being evaluated in an ongoing clinical trial (NCT 06014086) as a neoadjuvant intratumoral therapy for cutaneous malignancies, demonstrating ...

The exosomal Argonaute 2 (AGO2) protein forms a complex with siRNAs, which is essential for siRNA-mediated gene silencing in bacteria. Even though the delivered siRNA was designed for possessing ...

The exosomal Argonaute 2 (AGO2) protein forms a complex with siRNAs, which is essential for siRNA-mediated gene silencing in bacteria. Even though the delivered siRNA was designed for possessing ...

Fungal infections are on the rise globally. According to a study by the Manchester Fungal Infection Group, in 2022, ...

Junevity then develops novel silencing RNA (siRNA) therapeutics to restore cellular transcription back to a healthy state. Junevity’s preclinical data demonstrates the power of the RESET platform.

Eli Lilly's gene-silencing drug lepodisiran has been shown to reduce lipoprotein (a) levels by more than 90% for at least six ...

The US biotech has just reported phase 2 trial results with the small, interfering RNA (siRNA) gene-silencing drug showing that it an cause a 90% or greater reduction in Lp(a) levels – a risk ...

The study demonstrates that this RNAi approach shuts down vital fungal genes, thereby inhibiting pathogen growth - a ...

More information: Shireesha Manturthi et al, Nanoparticles Codelivering mRNA and SiRNA for Simultaneous Restoration and Silencing of Gene/Protein Expression In Vitro and In Vivo, ACS Nanoscience ...