Toll-like receptor 4 (TLR4) induces two distinct signaling pathways controlled by the TIRAP-MyD88 and TRAM-TRIF pairs of adaptor proteins, which elicit the production of proinflammatory cytokines ...

These results indicate that the engagement of TLR4 with MyD88 and TRIF is complex and must somehow depend on the conformation of TLR4, which in turn depends on the presence of CD14.

Iron is a micronutrient essential to the survival of both humans and disease-causing microbes. Changes in iron levels therefore affect the severity of infectious diseases. New research has now ...

TLR4 is the only TLR that activates both MyD88- and TRIF-dependent signaling pathways. CD14-dependent TLR4 internalization into endosomes from the plasma membrane facilitates induction of the TRIF ...

Before the TRIF gene was identified or named, Bruce Beutler's group had created a TRIF-deficient mouse using random germline mutagenesis, and picked the mutant animal from among many thousands of ...

Tumor growth was slightly reduced in mice lacking MYD88 or TRIF, but in mice lacking TLR4, tumor growth was no greater than in mice with undisturbed sleep. Taking TLR4 out of the picture resulted in ...

Romeo Trif is the definition of a team player. When the pandemic rocked his industry with unprecedented worker shortages, there were countless days where Trif was out in a semi-truck, delivering on ...

Lowenstein Sandler of Roseland, New Jersey and Cyrulnik Fattaruso of New York are accused of legal malpractice in a suit filed Tuesday by a trustee for Harmony Foundation.

Innate immune adaptor TRIF deficiency accelerates disease progression of ALS mice with accumulation of aberrantly activated astrocytes. Cell Death & Differentiation, 2018; DOI: 10.1038/s41418-018 ...

LPS and PLX binding to TLR4 on MyD88+ cells induced activation of PI3K/Akt, IRAK4, and IRAK1, but decreased expression of pro-apoptotic TRIF. In contrast, in MyD88 (-) cells LPS did not induce ...