Toll-like receptors (TLRs) use multiple downstream signaling pathways. New data suggest that components of the tumor necrosis factor receptor signaling pathway are involved in signal transduction ...

Mammalian Toll-like receptors (TLRs) recognize conserved products of microbial metabolism and activate NF-κB and other signaling pathways through the adapter protein MyD88. Although some cellular ...

Working on mice deficient in MyD88 (an essential protein in the classical Toll signaling pathway) they showed that TIRAP is part of an alternative signaling route for immune responses induced by ...

A University of Minnesota Medical School-led research team has discovered that a cancer signaling pathway has previously ...

Background: This study detailed and characterized the mechanisms of action of OncoTherad nano-immunotherapy based on modulation of Toll-like Receptor 4 (TLR4) signaling pathway, CX3C chemokine ...

Baylor College of Medicine. (2013, August 15). The pathway to asthma winds through toll-like receptor 4. ScienceDaily. Retrieved June 2, 2025 from www.sciencedaily.com / releases / 2013 / 08 ...

However, the team has demonstrated that toll-like receptor-dependent signaling pathways do converge on CARD9, but then are routed elsewhere. ITAM recruits an enzyme, Syk, known as a kinase to start a ...

Asthma is part of a battle that takes place as the immune system marshals its forces to fight off an invading organism-or what mimics such invaders. The ensuing fight takes a significant toll on ...