Sickle Cell Disease is a chronic, inherited blood disorder that affects millions of people worldwide. It is best known for causing anaemia, pain episodes, and organ complications, but a lesser-known ...

James Herrick, a Chicago doctor, was the first to describe sickled red blood cells in a patient of African descent. A series of rodent experiments showed that even with abundant food and water, ...

In SCD, oxidative stress is exacerbated by several factors: Chronic homolysis The rapid breakdown of sickled red blood cells releases free haemoglobin, which generates free radicals. Inflammation ...

Why is knowing the atomic structure of molecules useful? Learn why, and how information like this about protein structure is shared through a publicly available database.

Normal (left) and sickle cell (right) mouse red blood cells show the rigid, crescent-shaped "sickled" cells (arrows). Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news ...

Martin Mwita, 20, is the first patient in St. Louis and among the first across the country to receive a new gene therapy for sickle cell disease.

A Bahrain study shows CT scans to check for blood clots in lung blood vessels increased significantly in people with sickle ...

the abnormal form of the hemoglobin protein causes the red blood cells to lose oxygen and warp into a sickle shape during periods of high activity. These sickled cells become stuck in small blood ...

It has been shown to inhibit interactions between endothelial cells, platelets, red blood cells, sickled red blood cells, and leucocytes, causing a blockade and thereby preventing these cells from ...

red blood cells, sickled red blood cells, and leukocytes. P-selectin is one of the major drivers of the vaso-occlusive process. There are high hopes for Global Blood Therapeutics’ voxelotor that ...

However, the sickled red blood cells do not survive for long compared to normal red blood cells. Rae cited malaria and carbon monoxide (use of charcoal) as the common triggers that precipitate a ...