Filamentous bacteriophage fd can display multiple copies of foreign peptides in the N-terminal region of its major coat protein pVIII, 2,700 copies of which make up the virus capsid. Here we show ...

In a new study, researchers have screened nine heptapeptide sequences from a random peptide library using phage display technology, with S. aureus 6538 as the target bacterium. The work is ...

While Smith and his colleagues’ peptide libraries demonstrated the potential of phage display, the sequences were randomly generated. Scientists did not have control over the amino acid frequencies, ...

Scientists insert variable DNA sequences coding for their proteins of interest into plasmids that carry a phage coat protein gene, an antibiotic resistance gene, and a packaging signal. Then they ...

In phage display, billions of protein fragments, or peptides, can be screened based on their desired characteristics. Such a property could be, for example, their ability to bind to a specific ...

Bacteriophages (T4) were modified with anticancer Tyr–Ile–Gly–Ser–Arg (YIGSR) peptides by phage display and injected intraperitoneally. Results & conclusion: Tumor growth was decreased in ...

using the structure of the receptor’s binding site as a guide while also leveraging phage display technologies to pan massive libraries of peptides for hits for medicinal chemistry optimization.

for their work on phage display of peptides and antibodies. The other half of this year’s prize went to CalTech’s Frances Arnold for her work on directed evolution of enzymes, which can be ...

During four years, she focused her research on developing and perfecting the phage display technology and successfully discovered novel targeting peptides specific to the tumour tissue and tumour ...

Our laboratory is focusing on identification of metastasis and tumor cell invasion-associated molecules, by using advanced molecular biology and the phage display technology ... and screening of novel ...