While Smith and his colleagues’ peptide libraries demonstrated the potential of phage display, the sequences were randomly generated. Scientists did not have control over the amino acid frequencies, ...

Scientists insert variable DNA sequences coding for their proteins of interest into plasmids that carry a phage coat protein gene, an antibiotic resistance gene, and a packaging signal. Then they ...

Phage display technology involves the fusion of DNA fragments encoding exogenous proteins or small‐molecule polypeptides with phage genes encoding surface proteins, which then exist on the ...

They took a technique in which viruses are engineered to display bits of proteins like flags on their surface, called phage ...

UNC Greensboro is welcoming a Nobel Prize winner to its campus on Wednesday, March 19. George Smith, Ph.D., won the prize for ...

The screening method is based on combining phage display and microdialysis performed in a living organism with modern high throughput sequencing technologies. Phage display is a true 'golden goose ...

In this issue, Gishizky and coworkers describe yet another use for phage display—a method for mapping protein–protein interactions that is faster than two-hybrid systems and that allows the ...

Of the 23 fully human mAbs approved so far, 17 are derived from transgenic mice and 6 were developed with phage-display technology. Yeast display has generated a clinical pipeline, but no marketed ...

Their potential as antibacterial agents was appreciated almost immediately, with the first 'phage therapy' trials predating Fleming's discovery of penicillin by approximately a decade. In this ...