Researchers have captured the dynamic nature of nuclear pore complexes with AFM, reshaping our understanding of intracellular transport.

“With the high-speed AFM we could, for the first time, peer inside native nuclear pore complexes only forty nanometers in size,” study coauthor Roderick Lim of the University of Basel said in a ...

New mechanism determined for passive transport of biomolecules through the nuclear pore complex of cells. Research can help guide the development of future therapeutics for human diseases such as ...

Researchers at Kanazawa University report in Cell Reports how alterations in the nuclear pores lead to the degradation of anti-tumor proteins. Several types of cancer are believed to be linked to ...

If the cell nucleus is like a bank for DNA, nuclear pores are the security doors around its perimeter. Yet more security doors aren't necessarily better: some cancer cells contain a dramatic excess of ...

Each cell contains well-defined compartments, each of which has a specific function. The nuclear envelope, for example, is a highly regulated membrane barrier that separates the nucleus from the ...

Researchers have found that the stability of a protein next to its nuclear localization signal sequence impacts the rate of its entry into the nucleus. Recent research from The Francis Crick Institute ...

- Professors Hao F. Zhang and Xiaomin Bao’s groups used super-resolution imaging on human skin cells for the first time. - The researchers explored the gateways between the cells’ cytoplasm and ...

The human NPC is composed of approximately 34 nucleoporin proteins. The interior, or “symmetric,” core is composed of an inner ring, and two outer rings that sit on either side of the nuclear envelope ...

A model of transport through the nuclear pore complex. The blue spheres represent macromolecules that do not interact with the selectively permeable barrier of the complex, while the red spheres ...