Applications of the concept of drug-likeness, which involve consideration of how properties of chemicals such as lipophilicity compare with those of approved drugs, have become widely accepted as ...

However, their strong hydrophilicity and poor lipophilicity result in insufficient cell membrane permeability, and high doses are required to achieve therapeutic effects, which severely limits ...

The development of less toxic, liposomal formulations of cisplatin has been hampered by the low water solubility and low lipophilicity of cisplatin, resulting in very low encapsulation efficiencies.

POMs are a class of inorganic metal-oxygen cluster compounds with broad-spectrum antitumor potential. However, their strong hydrophilicity and poor ...