Our cells harbor a DNA detector termed cGAS to inform the immune system of viral and bacterial infections, cell death, as ...

IRF3 can then go to the nucleus to trigger transcription of inflammatory genes. This pathway plays a critical role in mediating immune defense against double-stranded DNA viruses. The innate immune ...

A research led by Sergio P. Acebrón, Researcher Ikerbasque at the UPV/EHU, develops a key tool to visualize the immune response to abnormal DNA, opening new avenues for the treatment of diseases.

As they dissected the signaling cascade of the MAVS pathway, Chen’s interest naturally turned to ... the cytoplasm and applied it to a second set of cells, where they tracked IRF3 activation as a sign ...