Remarkably, a single nucleotide change or methylation of the cytosine within the CpG motif was sufficient to completely eliminate the immunostimulatory activity of CpG oligonucleotides.
surprisingly found that some oligodeoxynucleotides (ODNs) carrying unmethylated CpG motifs inhibit the development of RA. In the K/BxN model, serum transferred from transgenic mice (which ...
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