Scientists have developed a new molecule that can deliver powerful immune-activating treatment directly to cancer cells, ...

Finally, TLR9 was shown to be required for NF-κB and JNK activation by CpG DNA. Taken together, these results clearly show that TLR9 is absolutely essential for CpG DNA (and by inference ...

TLR9 is a membrane-bound protein that detects these traces by recognizing a DNA sequence called Cytosine-phosphate-Guanine dinucleotide (CpG), a motif that is specific to bacteria and viruses.

Among the strongest 'triggers' for the secretion of IFN-α by pDCs are ligands for TLR9, such as CpG motifs in DNA, and for TLR7, such as immune-stimulatory RNA motifs 3, which are ligands often ...

Toll-like receptor 9 (TLR9), which is expressed by the body’s immune cells, “senses” foreign unmethylated CpG-rich DNA (CpG DNA) to trigger innate immune responses that are the first line of ...

The study proposes that ADA2's regulation of TLR9 activation in pDCs could explain the functional differences among the three classes of CpG ODNs and suggests that synergistic activation of TLR9 ...

CpG 1018 is a proprietary immune adjuvant made up of short, unmethylated cytosine-phosphate-guanine oligodeoxynucleotides (CpG ODNs). Its components mimic bacterial DNA to activate innate immunity ...

Checkmate Pharmaceuticals currently has one therapeutic in their pipeline known as Vidutolimod ("CMP-001"), a CPG-A TLR9 agonist, ... immune-stimulatory CpG DNA in 1994.

ABOVE: Researchers employ DNA origami (gray) to design cancer vaccines carrying tumor antigens (green) and CpG adjuvants (yellow) at DNA ends. Wyss Institute at Harvard University . T he immune system ...

The nanoscale distances between the CpG-binding domains in effective TLR9 assemblies revealed by structural analysis fell right into the range of what we hypothesized we could mirror with DNA ...

TLR9 is a membrane-bound protein that detects these traces by recognizing a DNA sequence called Cytosine-phosphate-Guanine dinucleotide (CpG), a motif that is specific to bacteria and viruses.