TLR9 binds unmethylated CpG DNA and sends signals from endolysosomes. Ploegh and colloeagues find that cleavage mediated by endolysosomal cathepsins is required for TLR9 activation. Toll-like ...

CpG DNA motifs in microbial DNA or synthetic oligodeoxynucleotides are known to activate TLR9 in innate immune cells and induce the secretion of pro-inflammatory cytokines.

Toll-like receptor 9 (TLR9), which is expressed by the body’s immune cells, “senses” foreign unmethylated CpG-rich DNA (CpG DNA) to trigger innate immune responses that are the first line of ...

TLR9 is a membrane-bound protein that detects these traces by recognizing a DNA sequence called Cytosine-phosphate-Guanine dinucleotide (CpG), a motif that is specific to bacteria and viruses.

Scientists have developed a new molecule that can deliver powerful immune-activating treatment directly to cancer cells, ...

Checkmate Pharmaceuticals currently has one therapeutic in their pipeline known as Vidutolimod ("CMP-001"), a CPG-A TLR9 agonist, ... immune-stimulatory CpG DNA in 1994.

TAC-001 is designed to systemically deliver T-CpG to B cells by binding to CD22, leading to internalization of TAC-001, TLR9 signaling, B cell activation and a cascade of immune reactions.

RBD formulated with AH:CpG induces robust production of anti-RBD neutralizing antibodies in young adult mice Young adult, 3-month-old BALB/c mice were immunized IM on Days 0 and 14 with 10 µg of ...

The researchers developed CpGPT, which includes over 100,000 human DNA methylation samples from more than 1,500 studies covering a diverse range of tissue types, developmental stages, and disease ...

To find out, they focused their efforts on CpG islands, which are present in approximately 60 percent of promoters in human genes; they are known as CGI + genes—those without them, quite ...