This article was originally published on www.si.com/college/lsu as Way-Too-Early Betting Lines: LSU Football vs. Clemson Tigers in Week 1 Matchup. Brian Kelly and the LSU Tigers will hit the road to Clemson in Week 1 for the program's highly anticipated season opener.

What fans have been waiting for since January is finally here because Week 1 of the college football season kicks

As LSU and Clemson get together this year, the attention will again be on the quarterbacks. Garrett Nussmeier and Cade Klubnik are both considered Heisman trophy contenders and in the conversation to be the No. 1 overall pick in the 2026 NFL Draft. Whoever leads their team to victory in week one will likely be the early-season Heisman favorite.